Estradiol protects the nervous system from the body’s fight against its effort to detoxify free radicals that damage all components of the cell, including proteins, lipids, and DNA. This stress is increased without estradiol, causing the toxic effects of free radicals, and is dangerous to the central nervous system. The consequences of being without the protection of estradiol may be neurodegenerative diseases including gene mutations, chronic fatigue syndrome, heart and blood vessels disorders, heart failures, heart attacks and inflammatory diseases. Further insults on the body come from disruptions in normal mechanisms of cellular signaling, which may cause cancer, Parkinson’s disease, Alzheimer’s atherosclerosis, fragile X syndrome, Sickle Cell Disease, lichen planus, vitiligo, autism, and chronic fatigue syndrome.

“Estrogen replacement therapy is associated with improvement of cognitive deficits and reduced incidence of Alzheimer’s disease.”

The beneficial effects of bio-identical estradiol was touted in an article published by The Endocrine Society in 2002: “Estrogen replacement therapy is associated with improvement of cognitive deficits and reduced incidence of Alzheimer’s disease. This combination, protected against glutamate toxicity. Without becoming too complicated, glutamate is a neurotransmitter. It is especially important in the brain to keep us thinking and remembering. Having just the right amount is paramount. Too much glutamate is toxic to the brain and results in memory loss and eventually Alzheimer’s. Estradiol and progesterone ,that are natural to humans, protect the brain from excess glutamate.

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