Progesterone is the other major hormone in a woman’s monthly cycle. It affects the brain in the following ways:

  • Supports GABA, which helps the brain relax
  • Protects your nerves
  • Supports the myelin that “insulates” and protects neurons

When progesterone is in balance with estrogen, it calms you, brings feelings of peacefulness, and promotes sleep. But when they are imbalanced or when the relaxation hormone drops too dramatically, calmness can give way to irritability, anxiety, depression, sleepless nights, and brain fog. For some women, when progesterone and estrogen plummet right before menstruation starts, mood stability goes out the window.


  • Anxiety/Depression
  • Trouble sleeping
  • Fibrocystic breasts
  • PMS
  • Premenstrual headaches
  • Postpartum depression
  • Bone loss